Macromolecular Cystatin C Can Be a Caveat for Estimating Glomerular Filtration Rate in Biliary Obstruction
نویسندگان
چکیده
منابع مشابه
Macromolecular cystatin C can be a caveat for estimating glomerular filtration rate in biliary obstruction.
heterozygotes, the mean -chain mass was 15 866.832 Da (0.039 Da SD), which is 0.423 Da lower than that determined for the normal -chain. This mass difference is readily detected and even allows the mean abundance of the variant -chain to be estimated as 43.0%, which agrees with the mean abundance determined from the HPLC data associated with each sample (41.0%, 3.2% SD, n ϭ 22). The above SD...
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PURPOSE OF REVIEW Glomerular filtration rate (GFR) is rarely measured in clinical practice because of the complexity of the measurement. As such, kidney function is typically estimated using validated study equations, which use readily available data including age, sex, race, and serum creatinine as filtration marker. Contemporary research suggests that cystatin C may be an improved alternative...
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Cystatin C is a 13 KD basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors. The cystatin C gene seems to be a house keeping gene, which is compatible with a stable production rate of cystatin C by most cells. This protein is freely filtered through the glomerulus and almost completely reabsorbed and catabolized by proximal tubular cells. Because of the...
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Assessment of glomerular filtration rate (GFR) is essential for clinical practice. GFR is difficult to measure [measured GFR (mGFR)]; instead it is estimated [estimated GFR (eGFR)] by use of the serum concentration of endogenous filtration markers. However, all endogenous filtration markers are affected by factors other than GFR (non-GFR determinants), including generation, renal tubular reabso...
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Background: Measurement of glomerular filtration rate (GFR) and monitoring of it in any patient on nephrotoxic drugs is very important. Recently, cystatin C (cys-C) has been introduced as a better marker for determining and monitoring renal function than creatinine especially in a mild decrease of GFR. This study was done to assess the change of GFR measurement based on serum Cys-C and creatini...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2008
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2008.103176